The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria

Complement C5 inhibition is the standard of care (SoC) for patients with paroxysmal nocturnal hemoglobinuria (PNH) with significant clinical symptoms. Constant and complete suppression of the terminal complement pathway and the high serum concentration of C5 pose challenges to drug development that...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Röth, Alexander, Nishimura, Jun-ichi, Nagy, Zsolt, Gaàl-Weisinger, Julia, Panse, Jens, Yoon, Sung-Soo, Egyed, Miklos, Ichikawa, Satoshi, Ito, Yoshikazu, Kim, Jin Seok, Ninomiya, Haruhiko, Schrezenmeier, Hubert, Sica, Simona, Usuki, Kensuke, Sicre de Fontbrune, Flore, Soret, Juliette, Sostelly, Alexandre, Higginson, James, Dieckmann, Andreas, Gentile, Brittany, Anzures-Cabrera, Judith, Shinomiya, Kenji, Jordan, Gregor, Biedzka-Sarek, Marta, Klughammer, Barbara, Jahreis, Angelika, Bucher, Christoph, Peffault de Latour, Régis
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Clinical Trials and Observations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7082616/
https://ncbi.nlm.nih.gov/pubmed/31978221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003399
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