Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources

Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic dosage, APAP is mainly metabolized by sulfation and glucuronidation, and partly by cytochr...

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Detalhes bibliográficos
Publicado no:Lab Anim Res
Main Authors: Jeong, Tae Bin, Kim, Joung-Hee, Kim, Sou Hyun, Lee, Seunghyun, Son, Seung Won, Lim, Yong, Cho, Joon-Yong, Hwang, Dae Youn, Kim, Kil Soo, Kwak, Jae-Hwan, Jung, Young-Suk
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081583/
https://ncbi.nlm.nih.gov/pubmed/32257904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s42826-019-0017-x
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