Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes

A number of recent papers report that standing genetic variation in natural populations includes ubiquitous polymorphisms within target sites for Cas9-based gene drive (CGD) and that these “drive resistant alleles” (DRA) preclude the successful application of CGD for managing these populations. Here...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Schmidt, Hanno, Collier, Travis C., Hanemaaijer, Mark J., Houston, Parker D., Lee, Yoosook, Lanzaro, Gregory C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080748/
https://ncbi.nlm.nih.gov/pubmed/32188851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15204-0
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk