Synthesis and preliminary in vitro activity of mono- and bis-1H-1,2,3-triazole-tethered β-lactam–isatin conjugates against the human protozoal pathogen Trichomonas vaginalis

In this study, we describe the synthesis of mono- and bis-1H-1,2,3-triazole-tethered β-lactam–isatin conjugates using copper-catalysed azide-alkyne cycloaddition reaction between mono- and di-propargylated azetidin-2-ones and N-alkylazido isatins. The synthesized conjugates were evaluated for their...

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Detalhes bibliográficos
Publicado no:Med Chem Res
Main Authors: Raj, Raghu, Sharma, Vaishali, Hopper, Melissa J., Patel, Neal, Hall, Dominique, Wrischnik, Lisa A., Land, Kirkwood M., Kumar, Vipan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080013/
https://ncbi.nlm.nih.gov/pubmed/32214766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-014-0956-6
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