Protective Properties of FOXO1 Inhibition in a Murine Model of Non-alcoholic Fatty Liver Disease Are Associated With Attenuation of ER Stress and Necroptosis

AIM: The pathogenesis of non-alcoholic fatty liver disease is currently unclear, however, lipid accumulation leading to endoplasmic reticulum stress appears to be pivotal in the process. At present, FOXO1 is known to be involved in NAFLD progression. The relationship between necroptosis and non-alco...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Ding, Hao-ran, Tang, Zhen-ting, Tang, Ning, Zhu, Zheng-yi, Liu, Han-yi, Pan, Chen-yan, Hu, An-yin, Lin, Yun-zhen, Gou, Peng, Yuan, Xian-wen, Cai, Jia-hui, Dong, Chun-long, Wang, Jing-lin, Ren, Hao-zhen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078343/
https://ncbi.nlm.nih.gov/pubmed/32218743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00177
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