FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1 expression in adipocytes and preadipocytes. S...

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Publicado no:Nat Commun
Main Authors: Shamsi, Farnaz, Xue, Ruidan, Huang, Tian Lian, Lundh, Morten, Liu, Yang, Leiria, Luiz O., Lynes, Matthew D., Kempf, Elena, Wang, Chih-Hao, Sugimoto, Satoru, Nigro, Pasquale, Landgraf, Kathrin, Schulz, Tim, Li, Yiming, Emanuelli, Brice, Kothakota, Srinivas, Williams, Lewis T., Jessen, Niels, Pedersen, Steen Bønløkke, Böttcher, Yvonne, Blüher, Matthias, Körner, Antje, Goodyear, Laurie J., Mohammadi, Moosa, Kahn, C. Ronald, Tseng, Yu-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078224/
https://ncbi.nlm.nih.gov/pubmed/32184391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15055-9
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