Pharmacological screening and transcriptomic functional analyses identify a synergistic interaction between dasatinib and olaparib in triple‐negative breast cancer

Identification of druggable vulnerabilities is a main objective in triple‐negative breast cancer (TNBC), where no curative therapies exist. Gene set enrichment analyses (GSEA) and a pharmacological evaluation using a library of compounds were used to select potential druggable combinations. MTT and...

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Publicat a:J Cell Mol Med
Autors principals: Corrales‐Sánchez, Verónica, Noblejas‐López, María del Mar, Nieto‐Jiménez, Cristina, Pérez‐Peña, Javier, Montero, Juan Carlos, Burgos, Miguel, Galán‐Moya, Eva M., Pandiella, Atanasio, Ocaña, Alberto
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077558/
https://ncbi.nlm.nih.gov/pubmed/32032474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14980
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