Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study

Impaired mitochondrial autophagy (mitophagy) and NLRP3 inflammasome activation have been incriminated in the pathogenesis of T2DM. Metformin besides being an insulin sensitizer also induces autophagy; however, its effect on mitophagy and NLRP3 activation in patients with T2DM still remains elusive....

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Vydáno v:J Cell Mol Med
Hlavní autoři: Bhansali, Shipra, Bhansali, Anil, Dutta, Pinaki, Walia, Rama, Dhawan, Veena
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7077543/
https://ncbi.nlm.nih.gov/pubmed/31975558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14834
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