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Impact of Mucin on Drug Diffusion: Development of a Straightforward In Vitro Method for the Determination of Drug Diffusivity in the Presence of Mucin

Mucosal drug delivery accounts for various administration routes (i.e., oral, vaginal, ocular, pulmonary, etc.) and offers a vast surface for the permeation of drugs. However, the mucus layer which shields and lubricates all mucosal tissues can compromise drugs from reaching the epithelial site, thu...

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Publicado en:Pharmaceutics
Main Authors: Falavigna, Margherita, Stein, Paul C., Flaten, Gøril Eide, di Cagno, Massimiliano Pio
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076515/
https://ncbi.nlm.nih.gov/pubmed/32079348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12020168
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