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Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy
Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration. The polycation was synthesized by derivatization of α,β-poly(N-2-hydroxyethyl)d,l-aspartamide (PHEA) with 1,2-Bis(3-ami...
Guardat en:
| Publicat a: | Pharmaceutics |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
MDPI
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7076449/ https://ncbi.nlm.nih.gov/pubmed/31979001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12020089 |
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