Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo

This work explored absorption efficacy via an in vivo imaging system and parallel artificial membrane penetration in indomethacin (IMC) solid dispersion (SD) systems. Two different polymer excipients—hydroxypropyl methylcellulose (HPMC) and Kollicoat IR as precipitation inhibitors (PIs)—combined wit...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Xi, Ziyue, Zhang, Wei, Fei, Yali, Cui, Mingshu, Xie, Luyao, Chen, Lu, Xu, Lu
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076385/
https://ncbi.nlm.nih.gov/pubmed/32050600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12020144
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