Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity

Most of Gram-positive bacteria anchor surface proteins to the peptidoglycan cell wall by sortase, a cysteine transpeptidase that targets proteins displaying a cell wall sorting signal. Unlike other bacteria, Clostridium difficile, the major human pathogen responsible for antibiotic-associated diarrh...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kang, Chia-Yu, Huang, I-Hsiu, Chou, Chi-Chi, Wu, Tsai-Yu, Chang, Jyun-Cyuan, Hsiao, Yu-Yuan, Cheng, Cheng-Hsuan, Tsai, Wei-Jiun, Hsu, Kai-Cheng, Wang, Shuying
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076211/
https://ncbi.nlm.nih.gov/pubmed/32005667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011322
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