SYN-007, an Orally Administered Beta-Lactamase Enzyme, Protects the Gut Microbiome from Oral Amoxicillin/Clavulanate without Adversely Affecting Antibiotic Systemic Absorption in Dogs

Beta-lactamases, enzymes produced by bacteria to degrade beta-lactam antibiotics, have been harnessed as therapeutics to protect the gut microbiome from damage caused by antibiotics. Proof-of-concept of this approach using SYN-004 (ribaxamase), a beta-lactamase formulated for oral delivery with intr...

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Publicado en:Microorganisms
Autores principales: Connelly, Sheila, Fanelli, Brian, Hasan, Nur A., Colwell, Rita R., Kaleko, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7074739/
https://ncbi.nlm.nih.gov/pubmed/31979034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms8020152
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