Comparison of in vitro Susceptibility of Mycobacteria Against PA-824 to Identify Key Residues of Ddn, the Deazoflavin-Dependent Nitroreductase from Mycobacterium tuberculosis

OBJECTIVE: PA-824 (Pretomanid), a bicyclic nitroimidazole drug, exhibits significant bactericidal activity toward Mycobacterium tuberculosis (MTB) in vitro and in vivo, but not against Mycobacterium smegmatis. Through catalytic bioreduction, deazaflavin-dependent nitroreductase (Ddn) within MTB dire...

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Bibliographic Details
Published in:Infect Drug Resist
Main Authors: Zhang, Fuzhen, Li, Shanshan, Wen, Shuan, Zhang, Tingting, Shang, Yuanyuan, Huo, Fengmin, Xue, Yi, Li, Ling, Pang, Yu
Format: Artigo
Language:Inglês
Published: Dove 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073430/
https://ncbi.nlm.nih.gov/pubmed/32210596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S240716
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