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APP Osaka Mutation in Familial Alzheimer’s Disease—Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance

Alzheimer’s disease is believed to begin with synaptic dysfunction caused by soluble Aβ oligomers. When this oligomer hypothesis was proposed in 2002, there was no direct evidence that Aβ oligomers actually disrupt synaptic function to cause cognitive impairment in humans. In patient brains, both so...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Tomiyama, Takami, Shimada, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073033/
https://ncbi.nlm.nih.gov/pubmed/32093100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041413
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