PDRN, a Bioactive Natural Compound, Ameliorates Imiquimod-Induced Psoriasis through NF-κB Pathway Inhibition and Wnt/β-Catenin Signaling Modulation

Nuclear factor-κB (NF-κB) plays a central role in psoriasis and canonical Wnt/β-catenin pathway blunts the immune-mediated inflammatory cascade in psoriasis. Adenosine A2A receptor activation blocks NF-κB and boosts the Wnt/β-catenin signaling. PDRN (Polydeoxyribonucleotide) is a biologic agonist of...

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Publicat a:Int J Mol Sci
Autors principals: Irrera, Natasha, Bitto, Alessandra, Vaccaro, Mario, Mannino, Federica, Squadrito, Violetta, Pallio, Giovanni, Arcoraci, Vincenzo, Minutoli, Letteria, Ieni, Antonio, Lentini, Maria, Altavilla, Domenica, Squadrito, Francesco
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072802/
https://ncbi.nlm.nih.gov/pubmed/32059361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21041215
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