A Genetic Polymorphism in the Pannexin1 Gene Predisposes for The Development of Endothelial Dysfunction with Increasing BMI

Endothelial dysfunction worsens when body mass index (BMI) increases. Pannexin1 (Panx1) ATP release channels regulate endothelial function and lipid homeostasis in mice. We investigated whether the Panx1-400A>C single nucleotide polymorphism (SNP), encoding for a gain-of-function channel, associa...

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Udgivet i:Biomolecules
Main Authors: Molica, Filippo, Quercioli, Alessandra, Montecucco, Fabrizio, Schindler, Thomas H., Kwak, Brenda R., Morel, Sandrine
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072696/
https://ncbi.nlm.nih.gov/pubmed/32023876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10020208
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