Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton

Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier. Perlecan deficiency leads to skeletal dysplasia in Schwartz-Jampel Syndrome (SJS) and is a risk fac...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Parajuli, Ashutosh, Pei, Shaopeng, Zhao, Hongbo, Martinez, Jerahme R., Lu, X. Lucas, Liu, X. Sherry, Farach-Carson, Mary C., Kirn-Safran, Catherine B., Wang, Liyun
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072656/
https://ncbi.nlm.nih.gov/pubmed/32013135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10020198
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