Rapid Assessment of Functional Avidity of Tumor-Specific T Cell Receptors Using an Antigen-Presenting Tumor Cell Line Electroporated with Full-Length Tumor Antigen mRNA

The functional avidity of T-cell receptor (TCR)-engineered T cells towards their cognate epitope plays a crucial role in successfully targeting and killing tumor cells expressing the tumor-associated antigen (TAA). When evaluating in vitro functional T-cell avidity, an important aspect that is often...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Campillo-Davo, Diana, Versteven, Maarten, Roex, Gils, De Reu, Hans, van der Heijden, Sanne, Anguille, Sébastien, Berneman, Zwi N., Van Tendeloo, Viggo F. I., Lion, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072428/
https://ncbi.nlm.nih.gov/pubmed/31972992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020256
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