De novo design of tunable, pH-driven conformational changes

The ability of naturally occurring proteins to change conformation in response to environmental changes is critical to biological function. Although there have been advances in the de novo design of stable proteins with a single, deep free-energy minimum, the design of conformational switches remain...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Science
Autori principali: Boyken, Scott E., Benhaim, Mark A., Busch, Florian, Jia, Mengxuan, Bick, Matthew J., Choi, Heejun, Klima, Jason C., Chen, Zibo, Walkey, Carl, Mileant, Alexander, Sahasrabuddhe, Aniruddha, Wei, Kathy Y., Hodge, Edgar A., Byron, Sarah, Quijano-Rubio, Alfredo, Sankaran, Banumathi, King, Neil P., Lippincott-Schwartz, Jennifer, Wysocki, Vicki H., Lee, Kelly K., Baker, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072037/
https://ncbi.nlm.nih.gov/pubmed/31097662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7897
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi