Structure-Based Design, Synthesis and Bioactivity of a New Anti-TNFα Cyclopeptide

As opposed to small molecules, macrocyclic peptides possess a large surface area and are recognised as promising candidates to selectively treat diseases by disrupting specific protein–protein interactions (PPIs). Due to the difficulty in predicting cyclopeptide conformations in solution, the de nov...

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Bibliographic Details
Published in:Molecules
Main Authors: Idress, Mohannad, Milne, Bruce F., Thompson, Gary S., Trembleau, Laurent, Jaspars, Marcel, Houssen, Wael E.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071015/
https://ncbi.nlm.nih.gov/pubmed/32093030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25040922
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