Safety, Tolerability, Pharmacokinetics, Target Occupancy, and Concentration‐QT Analysis of the Novel BTK Inhibitor Evobrutinib in Healthy Volunteers

Bruton's tyrosine kinase (BTK) is a key regulator of B cell receptor and Fc receptor signaling, and a rational therapeutic target for autoimmune diseases. This first‐in‐human phase I, double‐blind, placebo‐controlled trial investigated the safety, tolerability, pharmacokinetics (PK), target occ...

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Bibliographic Details
Published in:Clin Transl Sci
Main Authors: Becker, Andreas, Martin, Emily C., Mitchell, David Y., Grenningloh, Roland, Bender, Andrew T., Laurent, Julien, Mackenzie, Harald, Johne, Andreas
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070898/
https://ncbi.nlm.nih.gov/pubmed/31654487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12713
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