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Relationship Between Plasma Concentrations and Clinical Effects of Cariprazine in Patients With Schizophrenia or Bipolar Mania

Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure‐response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2,558 patients with schizophrenia or bipolar mania. Drug exposure metrics were explored fo...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Periclou, Antonia, Willavize, Susan, Jaworowicz, David, Passarell, Julie, Carrothers, Timothy, Ghahramani, Parviz, Durgam, Suresh, Earley, Willie, Kapás, Margit, Khariton, Tatiana
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070889/
https://ncbi.nlm.nih.gov/pubmed/31664765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12720
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