Relationship Between Plasma Concentrations and Clinical Effects of Cariprazine in Patients With Schizophrenia or Bipolar Mania

Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure‐response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2,558 patients with schizophrenia or bipolar mania. Drug exposure metrics were explored fo...

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Bibliografiske detaljer
Udgivet i:Clin Transl Sci
Main Authors: Periclou, Antonia, Willavize, Susan, Jaworowicz, David, Passarell, Julie, Carrothers, Timothy, Ghahramani, Parviz, Durgam, Suresh, Earley, Willie, Kapás, Margit, Khariton, Tatiana
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070889/
https://ncbi.nlm.nih.gov/pubmed/31664765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12720
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