Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies

Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that works under acute transcriptional control by several stimuli, including serum and glucocorticoids. It plays a significant role in the cancer progression and metastasis, as it regulates inflammation, apoptosis, hormo...

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Veröffentlicht in:Molecules
Hauptverfasser: Mohammad, Taj, Siddiqui, Shiza, Shamsi, Anas, Alajmi, Mohamed F., Hussain, Afzal, Islam, Asimul, Ahmad, Faizan, Hassan, Md. Imtaiyaz
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070812/
https://ncbi.nlm.nih.gov/pubmed/32070031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25040823
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