Contribution of TGF-β1 and Effects of Gene Silencer Pyrrole-Imidazole Polyamides Targeting TGF-β1 in Diabetic Nephropathy

TGF-β1 has been known to induce diabetic nephropathy with renal fibrosis and glomerulosclerosis. DNA-recognized peptide compound pyrrole-imidazole (PI) polyamides as novel biomedicines can strongly bind promoter lesions of target genes to inhibit its transcription. We have developed PI polyamide tar...

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Udgivet i:Molecules
Main Authors: Horikoshi, Shu, Fukuda, Noboru, Tsunemi, Akiko, Okamura, Makiyo, Otsuki, Masari, Endo, Morito, Abe, Masanori
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070568/
https://ncbi.nlm.nih.gov/pubmed/32093382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25040950
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