Constitutive expression of the cryptic vanG(Cd) operon promotes vancomycin resistance in Clostridioides difficile clinical isolates

OBJECTIVES: To describe, for the first time (to the best of our knowledge), the genetic mechanisms of vancomycin resistance in clinical isolates of Clostridioides difficile ribotype 027. METHODS: Clinical isolates and laboratory mutants were analysed: genomically to identify resistance mutations; by...

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Bibliografiske detaljer
Udgivet i:J Antimicrob Chemother
Main Authors: Shen, Wan-Jou, Deshpande, Aditi, Hevener, Kirk E, Endres, Bradley T, Garey, Kevin W, Palmer, Kelli L, Hurdle, Julian G
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069472/
https://ncbi.nlm.nih.gov/pubmed/31873741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz513
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