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Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

Chlamydia trachomatis infections are a global health problem and new approaches to treat C. trachomatis with drugs of high specificity would be valuable. A library of substituted ring fused 2-pyridones has been synthesized and evaluated for their ability to attenuate C. trachomatis infectivity. In v...

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Xehetasun bibliografikoak
Argitaratua izan da:Medchemcomm
Egile Nagusiak: Kulén, Martina, Núñez-Otero, Carlos, Cairns, Andrew G., Silver, Jim, Lindgren, Anders E. G., Wede, Emma, Singh, Pardeep, Vielfort, Katarina, Bahnan, Wael, Good, James A. D., Svensson, Richard, Bergström, Sven, Gylfe, Åsa, Almqvist, Fredrik
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Royal Society of Chemistry 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069368/
https://ncbi.nlm.nih.gov/pubmed/32206238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00405j
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