N-Glycans Mediate the Ebola Virus-GP1 Shielding of Ligands to Immune Receptors and Immune Evasion

The Ebola Virus (EBOV) glycoprotein (GP) sterically shields cell-membrane ligands to immune receptors such as human leukocyte antigen class-1 (HLA-I) and MHC class I polypeptide-related sequence A (MICA), thus mediating immunity evasion. It was suggested that the abundant N-glycosylation of the EBOV...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Iraqi, Muhammed, Edri, Avishay, Greenshpan, Yariv, Kundu, Kiran, Bolel, Priyanka, Cahana, Avishag, Ottolenghi, Aner, Gazit, Roi, Lobel, Leslie, Braiman, Alex, Porgador, Angel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068452/
https://ncbi.nlm.nih.gov/pubmed/32211339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.00048
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