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The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development

Mutations in the key transcription factor, SOX2, alone account for 20% of anophthalmia (no eye) and microphthalmia (small eye) birth defects in humans—yet its regulation is not well understood, especially on the post-transcription level. We report the unprecedented finding that the conserved RNA-bin...

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Foilsithe in:Hum Mol Genet
Main Authors: Dash, Soma, Brastrom, Lindy K, Patel, Shaili D, Scott, C Anthony, Slusarski, Diane C, Lachke, Salil A
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068108/
https://ncbi.nlm.nih.gov/pubmed/31814023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz278
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