IL-2/IL-2 Receptor Pathway Plays a Crucial Role in the Growth and Malignant Transformation of HTLV-1-Infected T Cells to Develop Adult T-Cell Leukemia

T cells infected with human T-cell leukemia virus type 1 (HTLV-1) transform into malignant/leukemic cells and develop adult T-cell leukemia (ATL) after a long latency period. The tax (transactivator from the X-gene region) and HBZ (HTLV-1 bZIP factor) genes of HTLV-1 play crucial roles in the develo...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Maeda, Michiyuki, Tanabe-Shibuya, Junko, Miyazato, Paola, Masutani, Hiroshi, Yasunaga, Jun-ichirou, Usami, Kazumasa, Shimizu, Akira, Matsuoka, Masao
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067701/
https://ncbi.nlm.nih.gov/pubmed/32210945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.00356
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