Alteration of Cellular Reduction Potential Will Change (64)Cu-ATSM Signal With or Without Hypoxia

Therapies targeting reductive/oxidative (redox) metabolism hold potential in cancers resistant to chemotherapy and radiation. A redox imaging marker would help identify cancers susceptible to redox-directed therapies. Copper(II)-diacetyl-bis(4-methylthiosemicarbazonato) (Cu-ATSM) is a PET tracer dev...

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Udgivet i:J Nucl Med
Main Authors: Floberg, John M., Wang, Lingjue, Bandara, Nilantha, Rashmi, Ramachandran, Mpoy, Cedric, Garbow, Joel R., Rogers, Buck E., Patti, Gary J., Schwarz, Julie K.
Format: Artigo
Sprog:Inglês
Udgivet: Society of Nuclear Medicine 2020
Fag:
Molecular Imaging
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067520/
https://ncbi.nlm.nih.gov/pubmed/31586008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.119.230805
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