Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Carbamylation is a post‐translational modification that can be detected on a range of proteins, including immunoglobulin (Ig)G, in several clinical conditions. Carbamylated IgG (ca‐IgG) was reported to lose its capacity to trigger complement activation, but the mechanism remains unclear. Because C1q...

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Pubblicato in:Clin Exp Immunol
Autori principali: Lubbers, R., Oostindie, S. C., Dijkstra, D. J., Parren, P. W. H. I., Verheul, M. K., Abendstein, L., Sharp, T. H., de Ru, A., Janssen, G. M. C., van Veelen, P. A., van den Bremer, E. T. J., Bleijlevens, B., de Kreuk, B.‐J., Beurskens, F. J., Trouw, L. A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066385/
https://ncbi.nlm.nih.gov/pubmed/31853959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.13411
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