Inhibition of Myostatin Reduces Collagen Deposition in a Mouse Model of Oculopharyngeal Muscular Dystrophy (OPMD) With Established Disease

BACKGROUND: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset muscle disease presented by ptosis, dysphagia, and limb weakness. Affected muscles display increased fibrosis and atrophy, with characteristic inclusion bodies in the nucleus. Myostatin is a negative regulator of muscle mass, and...

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Vydáno v:Front Physiol
Hlavní autoři: Harish, Pradeep, Forrest, Leysa, Herath, Shanti, Dickson, George, Malerba, Alberto, Popplewell, Linda
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066371/
https://ncbi.nlm.nih.gov/pubmed/32194441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00184
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