Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities

Snake venom serine proteases (SVSPs) are complex and multifunctional enzymes, acting primarily on hemostasis. In this work, we report the hitherto unknown inhibitory effect of a SVSP, named collinein-1, isolated from the venom of Crotalus durissus collilineatus, on a cancer-relevant voltage-gated po...

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Опубликовано в: :Sci Rep
Главные авторы: Boldrini-França, Johara, Pinheiro-Junior, Ernesto Lopes, Peigneur, Steve, Pucca, Manuela Berto, Cerni, Felipe Augusto, Borges, Rafael Junqueira, Costa, Tássia Rafaella, Carone, Sante Emmanuel Imai, Fontes, Marcos Roberto de Mattos, Sampaio, Suely Vilela, Arantes, Eliane Candiani, Tytgat, Jan
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066243/
https://ncbi.nlm.nih.gov/pubmed/32161292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61258-x
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