Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose

Chikungunya virus (CHIKV) is the causative pathogen of chikungunya fever, a mosquito-borne viral disease causing highly debilitating arthralgia that can persist for months and progress to chronic arthritis. Our previous studies have identified the CHIKV live-attenuated vaccine candidate CHIKV-NoLS....

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Abeyratne, Eranga, Tharmarajah, Kothila, Freitas, Joseph R., Mostafavi, Helen, Mahalingam, Suresh, Zaid, Ali, Zaman, Mehfuz, Taylor, Adam
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066069/
https://ncbi.nlm.nih.gov/pubmed/32194557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00304
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