Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming

Protein modification with ISG15 (ISGylation) represents a major type I IFN–induced antimicrobial system. Common mechanisms of action and species-specific aspects of ISGylation, however, are still ill defined and controversial. We used a multiphasic coxsackievirus B3 (CV) infection model with a first...

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Pubblicato in:Sci Adv
Autori principali: Kespohl, Meike, Bredow, Clara, Klingel, Karin, Voß, Martin, Paeschke, Anna, Zickler, Martin, Poller, Wolfgang, Kaya, Ziya, Eckstein, Johannes, Fechner, Henry, Spranger, Joachim, Fähling, Michael, Wirth, Eva Katrin, Radoshevich, Lilliana, Thery, Fabien, Impens, Francis, Berndt, Nikolaus, Knobeloch, Klaus-Peter, Beling, Antje
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065878/
https://ncbi.nlm.nih.gov/pubmed/32195343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay1109
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