Anti-domain 1 β2 glycoprotein antibodies increase expression of tissue factor on monocytes and activate NK Cells and CD8+ cells in vitro

BACKGROUND: β2-Glycoprotein I (β2GPI) represents the major antigenic target for antiphospholipid antibodies (aPL), with domain 1 (D1) being identified as a risk factor for thrombosis and pregnancy complications in APS. We aimed to analyse the ability of aPL, and particularly anti-D1 β2GPI, to stimul...

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Bibliographische Detailangaben
Veröffentlicht in:Auto Immun Highlights
Hauptverfasser: Manukyan, Gayane, Martirosyan, Anush, Slavik, Ludek, Margaryan, Sona, Ulehlova, Jana, Mikulkova, Zuzana, Hlusi, Antonin, Papajik, Tomas, Kriegova, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065342/
https://ncbi.nlm.nih.gov/pubmed/32127041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13317-020-00128-y
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