The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow‐growing mycobacteria

The final step in mycolic acid biosynthesis in Mycobacterium tuberculosis is catalysed by mycolyl reductase encoded by the Rv2509 gene. Sequence analysis and homology modelling indicate that Rv2509 belongs to the short‐chain fatty acid dehydrogenase/reductase (SDR) family, but with some distinct fea...

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Detalhes bibliográficos
Publicado no:Mol Microbiol
Main Authors: Javid, Asma, Cooper, Charlotte, Singh, Albel, Schindler, Steffen, Hänisch, Milena, Marshall, Robert L., Kalscheuer, Rainer, Bavro, Vassiliy N., Bhatt, Apoorva
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065075/
https://ncbi.nlm.nih.gov/pubmed/31785114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14437
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