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Decreased circulating CXCR3 + CCR9+T helper cells are associated with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of patients with Sjögren’s syndrome to facilitate their concerted migration

CCR9 + T helper (Th) cells can induce Sjögren‐like symptoms in mice and both CCR9 + Th cells and their ligand CCL25 are increased in the salivary glands of primary Sjögren's syndrome (pSS) patients. Increased circulating CCR9 + Th cells are present in pSS patients. CCR9 + Th cells are hyperresp...

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Bibliografiske detaljer
Udgivet i:Scand J Immunol
Main Authors: Blokland, Sofie L. M., Kislat, Andreas, Homey, Bernhard, Smithson, Glennda M., Kruize, Aike A., Radstake, Timothy R. D. J., van Roon, Joel A. G.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064901/
https://ncbi.nlm.nih.gov/pubmed/31733111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/sji.12852
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