HSP70 Inhibition Leads to the Activation of Proteasomal System under Mild Hyperthermia Conditions in Young and Senescent Fibroblasts

Aging has been characterized with the accumulation of oxidized proteins, as a consequence of progressive decline in proteostasis capacity. Among others, proteasomal system is an efficient protein turnover complex to avoid aggregation of oxidized proteins. Heat shock protein 70 (HSP70) is another cri...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Bozaykut, Perinur, Sozen, Erdi, Kaga, Elif, Ece, Asli, Ozaltin, Esra, Bergquist, Jonas, Kartal Ozer, Nesrin, Karademir Yilmaz, Betul
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064868/
https://ncbi.nlm.nih.gov/pubmed/32190179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/9369524
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