HSP70 Inhibition Leads to the Activation of Proteasomal System under Mild Hyperthermia Conditions in Young and Senescent Fibroblasts

Aging has been characterized with the accumulation of oxidized proteins, as a consequence of progressive decline in proteostasis capacity. Among others, proteasomal system is an efficient protein turnover complex to avoid aggregation of oxidized proteins. Heat shock protein 70 (HSP70) is another cri...

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Dettagli Bibliografici
Pubblicato in:Oxid Med Cell Longev
Autori principali: Bozaykut, Perinur, Sozen, Erdi, Kaga, Elif, Ece, Asli, Ozaltin, Esra, Bergquist, Jonas, Kartal Ozer, Nesrin, Karademir Yilmaz, Betul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064868/
https://ncbi.nlm.nih.gov/pubmed/32190179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/9369524
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