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HSP70 Inhibition Leads to the Activation of Proteasomal System under Mild Hyperthermia Conditions in Young and Senescent Fibroblasts

Aging has been characterized with the accumulation of oxidized proteins, as a consequence of progressive decline in proteostasis capacity. Among others, proteasomal system is an efficient protein turnover complex to avoid aggregation of oxidized proteins. Heat shock protein 70 (HSP70) is another cri...

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Bibliografske podrobnosti
izdano v:Oxid Med Cell Longev
Main Authors: Bozaykut, Perinur, Sozen, Erdi, Kaga, Elif, Ece, Asli, Ozaltin, Esra, Bergquist, Jonas, Kartal Ozer, Nesrin, Karademir Yilmaz, Betul
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064868/
https://ncbi.nlm.nih.gov/pubmed/32190179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/9369524
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