Development and Validation of a Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Asparagine in Human Serum

L-Asparagine (ASN) is the catalyze substrate of L-asparaginase (ASNase), which is an important drug for acute lymphoblastic leukemia (ALL) patients. The ASN level is found to be closely associated with the effectiveness of ASNase treatment. In this study, a hydrophilic interaction liquid chromatogra...

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Detalhes bibliográficos
Publicado no:Int J Anal Chem
Main Authors: Lu, Haoyang, Zeng, Xiaoyun, Yu, Lihua, Wang, Zhanzhang, Lin, Danna, Ni, Xiaojia, Shang, Dewei, Zhang, Ming, Hu, Jinqing, Deng, Shuhua, Zhu, Xiuqing, Chen, Yuqing, Xie, Huanshan, Yang, Lihua, Wen, Yuguan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064832/
https://ncbi.nlm.nih.gov/pubmed/32180807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/6980392
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