Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

Purmorphamine (PUR), an agonist of the Smoothened (Smo) receptor, has been shown to function as a neuroprotectant in acute experimental ischemic stroke. Its role in hypoxic-ischemic (HI) brain injury in neonatal mice remains unknown. Here we show that PUR attenuated acute brain injury, with a decrea...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Liu, Dexiang, Bai, Xuemei, Ma, Weiwei, Xin, Danqing, Chu, Xili, Yuan, Hongtao, Qiu, Jie, Ke, HongFei, Yin, Sen, Chen, Wenqiang, Wang, Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064623/
https://ncbi.nlm.nih.gov/pubmed/32194421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00204
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