The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3′,4′-di-deoxygenation via reduction and transamination activities

BACKGROUND: New semi-synthetic aminoglycoside antibiotics generally use chemical modifications to avoid inactivity from pathogens. One of the most used modifications is 3′,4′-di-deoxygenation, which imitates the structure of gentamicin. However, the mechanism of di-deoxygenation has not been clearly...

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Bibliographic Details
Published in:Microb Cell Fact
Main Authors: Chen, Xiaotang, Zhang, Hui, Zhou, Shaotong, Bi, Mingjun, Qi, Shizhou, Gao, Huiyuan, Ni, Xianpu, Xia, Huanzhang
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063804/
https://ncbi.nlm.nih.gov/pubmed/32156271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-020-01317-0
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