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Thermal and Chemical Unfolding of a Monoclonal IgG1 Antibody: Application of the Multistate Zimm-Bragg Theory
The thermal unfolding of a recombinant monoclonal antibody IgG1 (mAb) was measured with differential scanning calorimetry (DSC). The DSC thermograms reveal a pretransition at 72°C with an unfolding enthalpy of ΔH(cal) ∼200–300 kcal/mol and a main transition at 85°C with an enthalpy of ∼900–1000 kcal...
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| Publicat a: | Biophys J |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Biophysical Society
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7063443/ https://ncbi.nlm.nih.gov/pubmed/32049058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.12.037 |
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