CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms

Mice overexpressing the nuclear form of CREBH mainly in the liver (CREBH-Tg) showed suppression of high-fat high-sucrose (HFHS) diet-induced obesity accompanied by an increase in plasma fibroblast growth factor 21 (FGF21) levels. CREBH overexpression induced browning in inguinal white adipose tissue...

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Gepubliceerd in:iScience
Hoofdauteurs: Satoh, Aoi, Han, Song-iee, Araki, Masaya, Nakagawa, Yoshimi, Ohno, Hiroshi, Mizunoe, Yuhei, Kumagai, Kae, Murayama, Yuki, Osaki, Yoshinori, Iwasaki, Hitoshi, Sekiya, Motohiro, Konishi, Morichika, Itoh, Nobuyuki, Matsuzaka, Takashi, Sone, Hirohito, Shimano, Hitoshi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063134/
https://ncbi.nlm.nih.gov/pubmed/32151974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100930
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