Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration

Portal vein ligation (PVL) induces liver growth prior to resection. Associating liver partition and portal vein ligation (PVL plus transection=ALPPS) or the addition of the prolyl-hydroxylase inhibitor dimethyloxalylglycine (DMOG) to PVL both accelerate growth via stabilization of HIF-α subunits. Th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dirscherl, Konstantin, Schläpfer, Martin, Roth Z’graggen, Birgit, Wenger, Roland H, Booy, Christa, Flury-Frei, Renata, Fatzer, Rita, Aloman, Costica, Bartosch, Birke, Parent, Romain, Kurtcuoglu, Vartan, de Zélicourt, Diane, Spahn, Donat R., Beck Schimmer, Beatrice, Schadde, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062856/
https://ncbi.nlm.nih.gov/pubmed/32152325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60709-9
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