Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with a novel line of reporter mice tha...

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Publicado no:Nat Commun
Main Authors: Wakhloo, Debia, Scharkowski, Franziska, Curto, Yasmina, Javed Butt, Umer, Bansal, Vikas, Steixner-Kumar, Agnes A., Wüstefeld, Liane, Rajput, Ashish, Arinrad, Sahab, Zillmann, Matthias R., Seelbach, Anna, Hassouna, Imam, Schneider, Katharina, Qadir Ibrahim, Abdul, Werner, Hauke B., Martens, Henrik, Miskowiak, Kamilla, Wojcik, Sonja M., Bonn, Stefan, Nacher, Juan, Nave, Klaus-Armin, Ehrenreich, Hannelore
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062779/
https://ncbi.nlm.nih.gov/pubmed/32152318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15041-1
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