Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis

The presence of antiendothelial cell antibodies (AECAs) has been documented in Takayasu arteritis (TAK), a chronic granulomatous vasculitis. Here, we identify cell-surface autoantigens using an expression cloning system. A cDNA library of endothelial cells is retrovirally transfected into a rat myel...

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Publicat a:Nat Commun
Autors principals: Mutoh, Tomoyuki, Shirai, Tsuyoshi, Ishii, Tomonori, Shirota, Yuko, Fujishima, Fumiyoshi, Takahashi, Fumiaki, Kakuta, Yoichi, Kanazawa, Yoshitake, Masamune, Atsushi, Saiki, Yoshikatsu, Harigae, Hideo, Fujii, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062749/
https://ncbi.nlm.nih.gov/pubmed/32152303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15088-0
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