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Concepts for agonistic targeting of CD40 in immuno-oncology

TNF Receptor Superfamily (TNF-R-SF) signaling is a structurally well-defined event that requires proper receptor clustering and trimerization. While the TNF-SF ligands naturally exist as trivalent functional units, the receptors are usually separated on the cell surface. Critically, receptor assembl...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Richards, David M., Sefrin, Julian P., Gieffers, Christian, Hill, Oliver, Merz, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062441/
https://ncbi.nlm.nih.gov/pubmed/31403344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2019.1653744
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