T Cell Receptor Stimulation Enhances the Expansion and Function of CD19 Chimeric Antigen Receptor-Expressing T Cells

PURPOSE: Current protocols for CD19 chimeric antigen receptor expressing T cells (CD19.CAR T cells) require recipients to tolerate pre-infusion cytoreductive chemotherapy, and the presence of sufficient target antigen on normal or malignant B cells. EXPERIMENTAL DESIGN: We investigated whether addit...

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Publicado en:Clin Cancer Res
Autores principales: Lapteva, Natalia, Gilbert, Margaret, Diaconu, Iulia, Rollins, Lisa A., Al-Sabbagh, Mina, Naik, Swati, Krance, Robert A., Tripic, Tamara, Hiregange, Manasa, Raghavan, Darshana, Dakhova, Olga, Rouce, Rayne, Liu, Hao, Omer, Bilal, Savoldo, Barbara, Dotti, Gianpietro, Cruz, Conrad Russel, Sharpe, Keli, Gates, Melissa, Orozco, Aaron, Durett, April G., Pacheco, Elizabeth, Gee, Adrian P., Ramos, Carlos A., Heslop, Helen E., Brenner, Malcolm K., Rooney, Cliona M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062259/
https://ncbi.nlm.nih.gov/pubmed/31558475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3199
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